Preparation of pelargonic acid vesicles and sustained drug release

This study has selected the medium-chain saturated fatty acid pelargonic as raw material for first time, and added surface catalyst Tween 80 to aqueous solution form acid–Tween composite vesicles by a tension method. The compound vesicle was used encapsulate five heterocyclic drugs (cefazolin sodium, chlorpromazine hydrochloride, gemcitabine metronidazole, isoniazid), all of which have disadvantages when directly, effects on kinds were evaluated in terms encapsulation rate vitro sustained release simulated artificial intestinal fluid environment. results revealed that exhibit an efficiency above 45%, encapsulated achieve cumulative effect 6–10 h environment, is 35%. proves can be carrier drugs, this extend time action drugs. research illustrates potential application field medicine.